Finished it! I had a final time of just under 11 hours, and I died only 9 times. Man, the credits sequence is sad... Seeing the Ganados when they were still human, carrying out their lives before being turned into savages by Saddler is depressing.
Could it be that there were some survivors from the village after the end of RE 4? Assuming Leon, Ada, and Luis didn't kill every single Ganado, maybe those few that were still alive went back to normal after Saddler and his control Plaga were killed. I have the same suspicions about the Majini from RE 5, though it's never revealed where their controller is or how it was engineered to be different by Tricell.